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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12151999 B1

PDFFull Text
Date of Patent:
Nov. 26, 2024

Filed:

Mar. 15, 2024

Small molecule compounds having naphthylamine structure and application thereof

Applicant:

Hangzhou Phecdamed Co., Ltd., Hangzhou, CN;

Inventors:

Hongguang Xia, Hangzhou, CN;

Mengyang Fan, Hangzhou, CN;

Xufeng Cen, Hangzhou, CN;

Xiaoyan Xu, Hangzhou, CN;

Ronghai Wu, Hangzhou, CN;

Dong Liu, Hangzhou, CN;

Zhen Tian, Hangzhou, CN;

Assignee:

Hangzhou PhecdaMed Co., Ltd., Hangzhou, CN;

Attorney:

Cooley LLP

Primary Examiner:

Andrew D Kosar

Assistant Examiner:

Gillian A Hutter

Int. Cl.
CPC ...
C07C 311/21 (2006.01); A61K 31/18 (2006.01); A61K 31/337 (2006.01); A61K 31/381 (2006.01); A61K 31/402 (2006.01); A61K 31/41 (2006.01); A61K 31/415 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 31/42 (2006.01); A61K 31/433 (2006.01); A61K 31/44 (2006.01); C07D 207/06 (2006.01); C07D 231/18 (2006.01); C07D 249/04 (2006.01); C07D 249/12 (2006.01); C07D 257/04 (2006.01); C07D 261/10 (2006.01); C07D 285/06 (2006.01); C07D 305/08 (2006.01); C07D 333/34 (2006.01); C07D 333/62 (2006.01);
U.S. Cl.
CPC ...
C07C 311/21 (2013.01); A61K 31/18 (2013.01); A61K 31/337 (2013.01); A61K 31/381 (2013.01); A61K 31/402 (2013.01); A61K 31/41 (2013.01); A61K 31/415 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/433 (2013.01); A61K 31/44 (2013.01); C07D 207/06 (2013.01); C07D 231/18 (2013.01); C07D 249/04 (2013.01); C07D 249/12 (2013.01); C07D 257/04 (2013.01); C07D 261/10 (2013.01); C07D 285/06 (2013.01); C07D 305/08 (2013.01); C07D 333/34 (2013.01); C07D 333/62 (2013.01);
Abstract

The present application discloses small molecule compounds having a naphthylamine structure and an application thereof. In the present application, the structure of a compound having a structure as shown in general formula (I) is as shown in the drawing. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof that are provided by the present application or the pharmaceutical composition provided by the present application can selectively induce autophagy in damaged mitochondria without affecting or only weakly affecting normal mitochondria, and further have superior metabolic stability and pharmacokinetic properties, lower toxicity, and better druggability.

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