The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2024
Filed:
Apr. 13, 2020
The Johns Hopkins University, Baltimore, MD (US);
Jordan J. Green, Baltimore, MD (US);
Stephany Yi Tzeng, Baltimore, MD (US);
Kelly Rhodes, Baltimore, MD (US);
Giorgio Raimondi, Baltimore, MD (US);
Marcos Iglesias Lozano, Baltimore, MD (US);
Jamie Spangler, Baltimore, MD (US);
Jakub Tomala, Baltimore, MD (US);
Derek VanDyke, Baltimore, MD (US);
Randall A. Meyer, Baltimore, MD (US);
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Abstract
The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject.