The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2024
Filed:
Oct. 18, 2023
Synerk Biotech Limited, Hong Kong, HK;
Dong Yu, Westboro, MA (US);
Synerk Biotech Limited, , HK;
Abstract
The present disclosure relates to the technical field of small nucleic acid drug delivery, and particularly discloses a compound, a conjugate and uses thereof. The present disclosure provides a nucleic acid drug targeted delivery monomer and conjugate and a preparation method thereof, the monomer and the conjugate which is formed by the monomer and has a specific design structure can specifically deliver an active drug (or small nucleic acid) to a cell receptor (or surface) in a targeted manner and can be combined with the receptor. The conjugate connected with the active drug (or small nucleic acid) can improve the cell penetration capability of the nucleic acid drug and enhance the stability of the nucleic acid drug in cells owing to the structural characteristics of the conjugate, and can effectively solve the problem of directional delivery of the drug. The delivery monomer and the conjugate have the advantages of being simple in preparation process, suitable for delivery of various targeted drugs, very wide in application and the like.