The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2024

Filed:

Jan. 31, 2024
Applicant:

Janssen Pharmaceuticals, Inc., Titusville, NJ (US);

Inventors:

Mark Schmidt, Antwerp, BE;

Vanina Popova, Nijlen, BE;

Adam Savitz, Greenwich, CT (US);

Rama Melkote, Basking Ridge, NJ (US);

Wayne C. Drevets, Rancho Santa Fe, CA (US);

Srihari Gopal, Belle Mead, NJ (US);

Darrel Pemberton, Oud Turnhout, BE;

Chakradhar Lagishetty, King of Prussia, PA (US);

Iva Kezic, Antwerp, BE;

Assignee:

Janssen Pharmaceuticals, Inc., Titusville, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/40 (2006.01); A61K 9/00 (2006.01); A61P 25/24 (2006.01);
U.S. Cl.
CPC ...
A61K 31/40 (2013.01); A61K 9/0056 (2013.01); A61P 25/24 (2018.01);
Abstract

The disclosure provides methods for treating major depressive disorder in a human patient having moderate or severe anhedonia. The methods comprise administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof. In some embodiments, the patient had an inadequate response to other antidepressant therapy prior to treatment with aticaprant. In other embodiments, the other antidepressant therapy comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.


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