The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Dec. 06, 2022
Zhejiang University, Hangzhou, CN;
Ruiliang Bai, Hangzhou, CN;
Zhaoqing Li, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
This invention discloses a method for quantitatively measuring the water exchange rate across myelin sheath. The method involves the following steps: acquiring images using the FEXI sequence; identifying anisotropic regions and the orientation of neural fibers at each pixel within these regions; selecting images where the diffusion weighted directions are perpendicular to the orientation of neural fibers at each pixel within the anisotropic regions and numerically averaging the selected images; calculating the apparent exchange rate (AXR), the apparent diffusion coefficient (ADC), and the filter coefficient (σ) using the numerically averaged images, where AXR serves as a specific parameter reflecting the water exchange rate across myelin sheath. The method provided by this invention enables specific detection of the exchange process of water molecules inside and outside the myelin sheath and analysis of the apparent water exchange rate across myelin sheath.