The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Oct. 08, 2021
Applicant:
National Jewish Health, Denver, CO (US);
Inventor:
Milene Saavedra, Denver, CO (US);
Assignee:
National Jewish Health, Denver, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6883 (2018.01); G01N 33/537 (2006.01); G01N 33/68 (2006.01); G16B 40/00 (2019.01); G16B 40/30 (2019.01); G16C 99/00 (2019.01); G16H 50/30 (2018.01);
U.S. Cl.
CPC ...
G01N 33/537 (2013.01); C12Q 1/6883 (2013.01); G01N 33/68 (2013.01); G01N 33/6893 (2013.01); G16B 40/00 (2019.02); G16B 40/30 (2019.02); G16C 99/00 (2019.02); G16H 50/30 (2018.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01); G01N 2333/54 (2013.01); G01N 2333/705 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70535 (2013.01); G01N 2333/70596 (2013.01); G01N 2333/924 (2013.01); G01N 2333/96486 (2013.01); G01N 2400/40 (2013.01); G01N 2800/122 (2013.01); G01N 2800/125 (2013.01); G01N 2800/127 (2013.01); G01N 2800/50 (2013.01);
Abstract
The present invention is related to novel methods for categorizing and treating a population of subjects having cystic fibrosis (CF) and who are at risk of severe pulmonary exacerbation comprising detecting the expression levels of genes in a gene panel consisting of TLR2, ADAM9, PLXND1, CD163, CD36, CD64, CSPG2, IL32, HPSE, and HCA112 and aggressively treating the subject when the expression levels of the genes from the gene panel predicts the subject is at risk for severe pulmonary exacerbation.