The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Mar. 22, 2019
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Leonard I. Zon, Brookline, MA (US);
Elliott J. Hagedorn, Jamaica Plain, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/44 (2015.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 5/069 (2013.01); A61K 35/44 (2013.01); C12N 15/907 (2013.01); C12N 2501/60 (2013.01); C12N 2510/00 (2013.01);
Abstract
The technology described herein relates to compositions and methods of generating endothelial niche cells. Embodiments of the technology described herein comprise compositions, kits, vectors, and methods related to generating or engineering endothelial niche cells. One aspect comprises a method to generate/engineer endothelial niche cells, comprising expressing one or more transcription factors in an endothelial cell, wherein the one or more transcription factors are from the Ets family, the Sox family, and/or the Nuclear Hormone (NHR) family.