The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Dec. 28, 2022
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventor:
George Q. Daley, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0789 (2010.01); A61K 35/28 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0647 (2013.01); A61K 35/28 (2013.01); C12N 2500/24 (2013.01); C12N 2500/38 (2013.01); C12N 2500/44 (2013.01); C12N 2501/105 (2013.01); C12N 2501/115 (2013.01); C12N 2501/125 (2013.01); C12N 2501/14 (2013.01); C12N 2501/145 (2013.01); C12N 2501/15 (2013.01); C12N 2501/165 (2013.01); C12N 2501/2303 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2311 (2013.01); C12N 2501/26 (2013.01); C12N 2501/32 (2013.01); C12N 2501/41 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/605 (2013.01); C12N 2501/606 (2013.01); C12N 2501/608 (2013.01);
Abstract
Embodiments herein relate to in vitro production methods of hematopoietic stem cell (HSC) and hematopoietic stem and progenitor cell (HSPC) that have long-term multilineage hematopoiesis potentials upon in vivo engraftment. The HSC and HSPCs are derived from pluripotent stem cells-derived hemogenic endothelia cells (HE) by non-integrative episomal vectors-based gene transfer.