The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Jan. 30, 2019
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Eduardo Marbán, Los Angeles, CA (US);
Linda Cambier, Los Angeles, CA (US);
Geoffrey De Couto, Los Angeles, CA (US);
Assignee:
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 35/34 (2015.01); A61K 47/69 (2017.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); A61P 37/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1136 (2013.01); A61K 35/34 (2013.01); A61K 47/6911 (2017.08); A61P 9/00 (2018.01); A61P 13/12 (2018.01); A61P 37/02 (2018.01); C12N 2310/18 (2013.01);
Abstract
Some embodiments of the methods and compositions provided herein relate to treating a subject suffering from hypertension, a cardiac injury, or a metabolic disorder. Some embodiments include administering an exosome to a subject. Some embodiments include administering an oligonucleotide to the subject. In some embodiments, the oligonucleotide comprises a Y-RNA or Y-RNA fragment such as EV-YF1 or EV-YF1-U16. In some embodiments, the oligonucleotide or exosome also has a therapeutic effect on the subject.