The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 19, 2024

Filed:

Sep. 30, 2022
Applicant:

Nextgen Bioscience Co., Ltd., Seongnam-si, KR;

Inventors:

Bong Yong Lee, Seoul, KR;

Young Ah Shin, Seongnam-si, KR;

Mi Ji Lee, Anyang-si, KR;

Eun Jeong Kim, Seongnam-si, KR;

Shin Ae Kim, Suwon-si, KR;

Na Ra Han, Yongin-si, KR;

Soo Sung Kang, Bucheon-si, KR;

Su Jae Yang, Seoul, KR;

Minh Thanh La, Seoul, KR;

Assignee:

NEXTGEN BIOSCIENCE CO., LTD., Seongnam-si, KR;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 413/14 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); C07D 401/14 (2013.01); C07D 417/14 (2013.01);
Abstract

Provided are a piperidine derivative compound, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for the prevention or treatment of diseases related to autotaxin activity, comprising same as an active ingredient, in which the piperidine derivative compound exhibits excellent inhibitory activity against autotaxin, and thus can be effectively used in the treatment and prevention of diseases related to autotaxin inhibition, such as fibrotic diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, metabolic diseases, cancer and cancer metastasis, ocular diseases, cholestatic form and other forms of chronic pruritus, and acute or chronic organ transplant rejection.


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