The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Feb. 03, 2019
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Yechun Xu, Shanghai, CN;
Hong Liu, Shanghai, CN;
Wei Tang, Shanghai, CN;
Xianglei Zhang, Shanghai, CN;
Zhanni Gu, Shanghai, CN;
Heng Li, Shanghai, CN;
Xu Han, Shanghai, CN;
Fenghua Zhu, Shanghai, CN;
Chunlan Feng, Shanghai, CN;
Guangyu Dong, Shanghai, CN;
Tiantian Chen, Shanghai, CN;
Wuyan Chen, Shanghai, CN;
Hualiang Jiang, Shanghai, CN;
Kaixian Chen, Shanghai, CN;
Abstract
Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis.