The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 19, 2024

Filed:

Dec. 06, 2019
Applicant:

Intrabio Ltd., London, GB;

Inventor:

Michiko Mann, Oxford, GB;

Assignee:

INTRABIO LTD., London, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 233/47 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07C 233/47 (2013.01); C07B 59/001 (2013.01);
Abstract

The present disclosure provides compounds represented by Formula I: I, and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, and Rare as defined as set forth in the specification, and the deuterium enrichment of any one or more of R, R, R, R, R, R, R, R, R, R, and Ris about 15% or more. The present disclosure also provides compounds having Formula I for use to treat or delay the progression of a lysosomal storage disorder or a neurodegenerative disease in a subject, provide neuroprotection in a subject having a lysosomal disorder, treat or prevent a migraine, and the symptoms associated therewith, in a subject, or improve mobility and/or cognitive function in a subject.


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