The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Jul. 18, 2022
Applicant:
Wisconsin Alumni Research Foundation (Warf), Madison, WI (US);
Inventors:
Yoshihiro Kawaoka, Middleton, WI (US);
Gabriele Neumann, Madison, WI (US);
Huihui Kong, Madison, WI (US);
Assignee:
Wisconsin Alumni Research Foundation (WARF), Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C07K 16/10 (2006.01); C07K 16/34 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); C07K 16/1018 (2013.01); C07K 16/34 (2013.01); C12N 15/86 (2013.01); A61K 2039/521 (2013.01); A61K 2039/5258 (2013.01);
Abstract
Methods of preparing influenza viruses having altered immunodominant epitopes in HA, e.g., having one or more residues in one or more of antigenic sites A-E in HA altered, and viral vectors, e.g., influenza virus VLPs or non-influenza viruses or VLPs thereof expressing or having influenza HAs with altered immunogenicity as a result of altered immunodominant epitopes therein are provided.