The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Apr. 18, 2023
Applicant:
Allergan, Inc., Irvine, CA (US);
Inventors:
Maurice Abiad, Anaheim, CA (US);
Bhas Dani, San Diego, CA (US);
Evgenyi Shalaev, Dana Point, CA (US);
Assignee:
Allergan, Inc., Irvine, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01); A61K 38/16 (2006.01); A61K 38/48 (2006.01); A61K 47/10 (2017.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61P 9/06 (2006.01); A61P 13/00 (2006.01); A61P 21/00 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4893 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 38/164 (2013.01); A61K 38/48 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); A61P 9/06 (2018.01); A61P 13/00 (2018.01); A61P 21/00 (2018.01); A61P 25/24 (2018.01); A61P 29/00 (2018.01);
Abstract
Pharmaceutical compositions that stabilize a Clostridial toxin active ingredient are described. The compositions can be liquid or solid compositions, and comprise a surfactant and an antioxidant. In some embodiments, the compositions comprise a surfactant selected from a poloxamer and a polysorbate; an antioxidant selected from methionine, N-acetyl cysteine, ethylenediaminetetraacetic acid and combinations thereof, and, optionally, a tonicity agent and/or a lyoprotector selected from, for example, trehalose, sucrose.