The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Apr. 13, 2023
Institut Gustave Roussy, Villejuif, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale—inserm, Paris, FR;
Universite Paris-saclay, Gif-sur-Yvette, FR;
Institut National DE Recherche Pour L'agriculture, L'alimentation ET L'environnement, Paris, FR;
Laurence Zitvogel, Paris, FR;
Bertrand Routy, Paris, FR;
Emmanuelle Le Chatelier, Magny les Hameaux, FR;
INSTITUT GUSTAVE ROUSSY, Villejuif, FR;
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM, Paris, FR;
UNIVERSITE PARIS-SACLAY, Gif-sur-Yvette, FR;
Institut national de recherche pour l'agriculture, l'alimentation et l'environnement, Paris, FR;
Abstract
The invention relates to gut microbiota profiles associated with response or resistance to treatments with ICB, in particular with anti-PD1 or anti PD-L1 or anti-PD-L2 antibodies. In particular, the invention pertains to a theranostic method for identifying good responders, to whom an anti-PD1 or anti PD-L1 or anti-PD-L2 can be administered, while a pre-treatment based on FMT and/or immunogenic probiotics is recommended to bad responders exhibiting a dysbiosis. In particular, the present invention pertains toas the main commensal species distinguishing responders from progressors and its use alone or withfor the treatment of antibiotics or gut repertoire insufficiency-associated dysbiosis.