The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Jul. 26, 2024
Kudos Pharmaceuticals Limited, Cambridge, GB;
Michael Karl Bechtold, Macclesfield, GB;
Julie Kay Cahill, Macclesfield, GB;
Katja Maren Fastnacht, Macclesfield, GB;
Kieran James Lennon, Macclesfield, GB;
Bernd Harald Liepold, Macclesfield, GB;
Claudia Bettina Packhaeuser, Macclesfield, GB;
Benedikt Steitz, Macclesfield, GB;
KUDOS PHARMACEUTICALS LIMITED, Cambridge, GB;
Abstract
The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.