The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Jun. 18, 2021
Applicant:
Cancer Vaccine Institute, London, GB;
Inventors:
Angus Dalgleish, London, GB;
Wai Liu, London, GB;
Assignee:
LDN PHARMA LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 31/282 (2006.01); A61K 31/436 (2006.01); A61K 31/664 (2006.01); A61K 31/7068 (2006.01); A61K 45/06 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 31/282 (2013.01); A61K 31/436 (2013.01); A61K 31/664 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); G01N 33/57484 (2013.01); G01N 2333/4703 (2013.01); G01N 2510/00 (2013.01);
Abstract
The disclosure provides methods of treating a tumor/cancer by administering naltrexone or an analogue thereof, followed by a recovery phase, and then administering a small molecule signaling inhibitor such as PI3-kinase inhibitors, AKT inhibitors, taxanes, antimetabolites, alkylating agents and/or cell cycle inhibitors. The disclosure also provides diagnostic methods for assessing a therapeutic response to the methods of treatment.