The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Dec. 29, 2022
Applicant:
Quest Diagnostics Investments Incorporated, Wilmington, DE (US);
Inventors:
Yanni Zhang, Mission Viejo, CA (US);
Nigel J. Clarke, San Clemente, CA (US);
Richard E Reitz, Las Vegas, NV (US);
Assignee:
Quest Diagnostics Investments Incorporated, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/78 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); G01N 33/68 (2013.01); G01N 33/6893 (2013.01); G01N 33/78 (2013.01); G01N 2800/52 (2013.01); G01N 2800/7028 (2013.01); Y10T 436/24 (2015.01);
Abstract
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.