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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12139816 B1

PDFFull Text
Date of Patent:
Nov. 12, 2024

Filed:

Nov. 08, 2021

Protease-resistant systems for polypeptide display and methods of making and using thereof

Applicant:

Cytomx Therapeutics, Inc., South San Francisco, CA (US);

Inventors:

Sherry Lynn La Porte, San Francisco, CA (US);

Stephen James Moore, Danville, CA (US);

James William West, Bend, OR (US);

Assignee:

CytomX Therapeutics, Inc., South San Francisco, CA (US);

Attorney:

Rothwell, Figg, Ernst & Manbeck, P.C.

Primary Examiner:

Christian C Boesen

Int. Cl.
CPC ...
C40B 30/06 (2006.01); C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 15/10 (2006.01); C12Q 1/37 (2006.01); G01N 33/68 (2006.01); C40B 40/02 (2006.01);
U.S. Cl.
CPC ...
C40B 30/06 (2013.01); C07K 14/001 (2013.01); C07K 14/705 (2013.01); C07K 16/18 (2013.01); C07K 16/2809 (2013.01); C07K 16/2866 (2013.01); C12N 15/1037 (2013.01); C12N 15/1044 (2013.01); C12Q 1/37 (2013.01); G01N 33/6845 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/21 (2013.01); C40B 40/02 (2013.01);
Abstract

The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.

Find Patent Forward Citations

La Porte, Sherry. (2024). Protease-resistant systems for polypeptide display and methods of making and using thereof (U.S. Patent No. 12139816). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12139816

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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