The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2024

Filed:

Jul. 06, 2018
Applicant:

Wacker Chemie Ag, Munich, DE;

Inventors:

Johanna Koch, Munich, DE;

Markus Brunner, Mering, DE;

Assignee:

WACKER CHEMIE AG, Munich, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C07K 1/14 (2006.01); C07K 14/775 (2006.01); C12N 15/70 (2006.01); C12R 1/19 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07K 1/14 (2013.01); C07K 14/775 (2013.01); C12N 15/70 (2013.01); C12R 2001/19 (2021.05);
Abstract

A bacterial strain suitable for expressing recombinant proteins contains an open reading frame which codes for a recombinant protein, under control of a functional promoter. The bacterial strain contains an open reading frame which codes for a muted peptidologycan-associated lipoprotein (PAL protein), under control of a functional promoter, wherein the PAL protein is muted such that it contains no membrane anchor for the outer cell membrane of the bacterial strain. A plasmid codes for a recombinant protein. Fermentative production of recombinant protein is facilitated by using the bacterial strain, with increased product yields in the culture residue without leading to a substantial die-off of the bacterial cells.


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