The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Nov. 22, 2021
Applicant:
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Henry Bernard Lowman, El Granada, CA (US);
Luc Roland Desnoyers, San Francisco, CA (US);
Shouchun Liu, Burlingame, CA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); G01N 33/564 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 39/39533 (2013.01); A61K 47/6817 (2017.08); A61K 47/6849 (2017.08); G01N 33/564 (2013.01); G01N 33/57492 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/50 (2013.01); G01N 2333/71 (2013.01); G01N 2800/205 (2013.01);
Abstract
The invention relates generally to variant activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these variant anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.