The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
May. 27, 2021
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Eureka Therapeutics, Inc., Emeryville, CA (US);
Renier J. Brentjens, Short Hills, NJ (US);
Eric L. Smith, Brookline, MA (US);
Cheng Liu, Emeryville, CA (US);
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
EUREKA THERAPEUTICS INC., Emeryville, CA (US);
Abstract
The presently disclosed subject matter provides for methods and compositions for treating a neoplasia (e.g., multiple myeloma). It relates to chimeric antigen receptors (CARs) that specifically target Fc Receptor-like 5 (FcRL5), e.g., domain 9 of FcRL5, and immunoresponsive cells comprising such CARs. The presently disclosed FcRL5-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.