The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Dec. 04, 2018
The Medical Research Infrastructure and Health Services Fund of the Tel Aviv Medical Center, Tel Aviv, IL;
Yeda Research and Development Co. Ltd., Tel Aviv, IL;
Zelig Eshhar, Tel Yitzhak, IL;
Tova Waks, Petach Tikva, IL;
Anat Globerson Levin, Tel Aviv, IL;
Naamit Deshet-Unger, Ramat Gan, IL;
Moran Rawet Slobodkin, Tel Aviv, IL;
Dan Grisaru, Herzlia, IL;
Ben Zion Katz, Rehovot, IL;
Ido Laskov, Tel Aviv, IL;
Abstract
The present invention provides T-cells modified to express at least two chimeric antigen receptors, wherein one of the CARs binds specifically to an antigen selected from CD138, HER2 and CD24 and another CAR binds specifically a different antigen selected from CD 138, HER2 and CD24. Further, the invention provides pharmaceutical compositions comprising these CAR T-cells and their use in treatment of cancer, in particular, ovarian cancer, DNA constructs encoding said CARs and methods for preparation of T-cells expressing said CARs.