The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2024

Filed:

Jan. 09, 2018
Applicants:

Central Adelaide Local Health Network Inc., Adelaide, AU;

The University of Melbourne, Victoria, AU;

Inventors:

Leanne Michelle Dibbens, College Park, AU;

Ingrid Eileen Scheffer, Victoria, AU;

Samuel Frank Berkovic, Victoria, AU;

John Charles Mulley, South Australia, AU;

Jozef Gecz, South Australia, AU;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); C12Q 1/6876 (2018.01); G01N 33/566 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 48/005 (2013.01); C12Q 1/6883 (2013.01); G01N 33/566 (2013.01); A01K 2217/05 (2013.01); A01K 2267/0356 (2013.01); A61K 38/00 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/172 (2013.01); G01N 2800/2857 (2013.01);
Abstract

Methods and kits for the diagnosis of illnesses related to protocadherin 19 (PCDH19) protein deficiency or altered PCDH19 protein function are provided, as well as methods and kits for the identification of a predisposition to such illnesses and methods of screening subjects to identify carriers of such illnesses and methods and kits for the therapeutic or prophylactic treatment of PCDH19 deficiency or altered PCDH19 protein function. Further, nucleotide and amino acid sequences corresponding to a complete PCDH19 open reading frame (ORF), mutant sequences encoding non-functional PCDH19 mRNA or altered PCDH19 mRNA are described along with transformed cells and non-human transgenic animals comprising wild-type or mutant PCDH19 ORF nucleotide sequences.


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