The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Feb. 02, 2023
Fc glycan remodeling platform method for site-specific antibody conjugation and applications thereof
Applicant:
University of Maryland, College Park, MD (US);
Inventors:
Lai-Xi Wang, Ellicott City, MD (US);
Xiao Zhang, Xuzhou, CN;
Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK, College Park, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); C07K 1/12 (2006.01); C12N 9/10 (2006.01); C12N 9/24 (2006.01);
U.S. Cl.
CPC ...
C07K 1/12 (2013.01); C07K 16/00 (2013.01); C12N 9/2402 (2013.01); C12Y 302/01096 (2013.01); C07K 2317/41 (2013.01);
Abstract
The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.