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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12139497 B1

PDFFull Text
Date of Patent:
Nov. 12, 2024

Filed:

Mar. 21, 2023

Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

Applicant:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Inventors:

Jason Allan Wiles, Madison, CT (US);

Avinash S. Phadke, Branford, CT (US);

Milind Deshpande, Madison, CT (US);

Atul Agarwal, Hamden, CT (US);

Dawei Chen, Guilford, CT (US);

Venkat Rao Gadhachanda, Hamden, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Godwin Pais, Hamden, CT (US);

Qiuping Wang, Bethany, CT (US);

Xiangzhu Wang, Branford, CT (US);

Assignee:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
C07D 513/04 (2006.01); A61K 31/167 (2006.01); A61K 31/395 (2006.01); A61K 31/40 (2006.01); A61K 31/416 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 38/00 (2006.01); A61P 1/16 (2006.01); A61P 3/06 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 13/02 (2006.01); A61P 17/00 (2006.01); A61P 19/02 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 27/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 493/04 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 493/04 (2013.01); C07D 495/04 (2013.01);
Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

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