The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2024

Filed:

Apr. 09, 2024
Applicants:

Technical Institute of Physics and Chemistry, Cas, Beijing, CN;

Beijing Cas Microneedle Technology Ltd., Beijing, CN;

Inventors:

Yunhua Gao, Beijing, CN;

Aguo Cheng, Beijing, CN;

Han Liu, Beijing, CN;

Suohui Zhang, Beijing, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/00 (2006.01); A61K 47/06 (2006.01); A61K 47/10 (2017.01); A61K 47/20 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61M 37/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0021 (2013.01); A61K 31/658 (2023.05); A61K 47/06 (2013.01); A61K 47/10 (2013.01); A61K 47/20 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01);
Abstract

A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.


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