The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Sep. 22, 2021
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); C07B 59/00 (2006.01); C07C 49/248 (2006.01); C07C 49/252 (2006.01); C07F 5/02 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0453 (2013.01); A61K 51/04 (2013.01); A61K 51/0455 (2013.01); C07B 59/002 (2013.01); C07C 49/248 (2013.01); C07C 49/252 (2013.01); C07F 5/02 (2013.01); A61K 2123/00 (2013.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); C07B 2200/05 (2013.01); C07F 5/022 (2013.01);
Abstract
Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.