The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2024
Filed:
Sep. 05, 2019
Applicant:
Duke University, Durham, NC (US);
Inventors:
Rory Henderson, Durham, NC (US);
S. Munir Alam, Durham, NC (US);
Barton F. Haynes, Durham, NC (US);
Kevin J. Wiehe, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/16 (2006.01); C12N 7/00 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); C07K 14/162 (2013.01); C12N 7/00 (2013.01); C12N 15/63 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01);
Abstract
The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use.