The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2024
Filed:
Nov. 27, 2019
Applicants:
Oregon Health & Science University, Portland, OR (US);
Aronora, Inc., Portland, OR (US);
Inventors:
Michael Wallisch, Portland, OR (US);
Andras Gruber, Portland, OR (US);
Erik I. Tucker, Portland, OR (US);
Christina U. Lorentz, Portland, OR (US);
Assignees:
Oregon Health & Science University, Portland, OR (US);
Aronora, Inc., Portland, OR (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/36 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 49/00 (2006.01); A61P 7/02 (2006.01);
U.S. Cl.
CPC ...
C07K 16/36 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 49/0002 (2013.01); A61P 7/02 (2018.01); A61K 39/00 (2013.01); A61K 2039/545 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01);
Abstract
Monoclonal antibodies that bind, such as specifically bind, blood protein factor XII (FXII) are described. The monoclonal antibodies (including antigen-binding fragments thereof) are capable of forming immune complexes with human FXII and inhibiting FXII activity, resulting in safe anti-inflammatory and anti-thrombotic effects.