The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2024
Filed:
Nov. 06, 2018
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventor:
Amy Han, Hockessin, DE (US);
Assignee:
REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/566 (2006.01); A61K 31/58 (2006.01); A61K 47/61 (2017.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); A61P 29/00 (2006.01); C07J 41/00 (2006.01); C07J 71/00 (2006.01);
U.S. Cl.
CPC ...
C07J 71/0026 (2013.01); A61K 31/566 (2013.01); A61K 31/58 (2013.01); A61K 47/61 (2017.08); A61K 47/6801 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61K 47/6951 (2017.08); A61P 29/00 (2018.01); C07J 41/005 (2013.01); C07J 41/0088 (2013.01); C07J 71/0031 (2013.01);
Abstract
Described herein protein drug conjugates and compositions thereof that are useful, for example, for the target-specific delivery of drugs to cells. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced. In certain embodiments, compounds, compositions, and conjugates are provided, which include hydrophilic residues in linker-payloads and protein conjugates thereof.