The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2024
Filed:
Apr. 01, 2021
Applicant:
Provecs Medical Gmbh, Hamburg, DE;
Inventors:
Frank Schnieders, Hamburg, DE;
Andrea Miegel, Hamburg, DE;
Carolin Biermann-Fleischhauer, Ahrensburg, DE;
Assignee:
PROVECS MEDICAL GMBH, Hamburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/70 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07H 21/04 (2006.01); C07K 14/54 (2006.01); C07K 14/55 (2006.01); C07K 14/705 (2006.01); C12N 15/86 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 48/0016 (2013.01); A61K 48/0075 (2013.01); A61K 48/0083 (2013.01); A61K 48/0091 (2013.01); A61P 31/12 (2018.01); A61P 35/00 (2018.01); C07K 14/5434 (2013.01); C07K 14/55 (2013.01); C07K 14/70532 (2013.01); C07K 14/70575 (2013.01); C12N 15/86 (2013.01); C12N 2710/10043 (2013.01); C12N 2840/203 (2013.01); C12N 2840/206 (2013.01);
Abstract
A method of treating cancer, a viral infection and/or an immune system disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a vector, wherein the vector comprises (a) nucleic acid sequences encoding 4-1BB ligand (4-1BBL), single chain IL-12 (scIL-12) and IL-2, and (b) at least one regulatory nucleic acid sequence providing for an increased expression level of 4-1BBL as compared to the expression levels of scIL-12 and IL-2, and other related methods.