The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2024
Filed:
Sep. 11, 2020
Jiangnan University, Wuxi, CN;
Jiangnan University, Wuxi, CN;
Abstract
The disclosure discloses a chemical synthesis method of oligosaccharides of aserotype O11 O-antigen, and belongs to the field of chemistry. The disclosure includes constructing an O-antigen trisaccharide by using a D-glucose building block, an L-fucosamine building block and a D-fucosamine building block; wherein the D-glucose building block or the L-fucosamine building block is linked with the D-fucosamine building block through a 1,2-α-cis-glycosidic bond, the D-glucose building block is linked with the L-fucosamine building block through a 1,2-β-trans-glycosidic bond, and the construction of the 1,2-α-cis-glycosidic bond is conducted in a mixed solvent; and the mixed solvent includes two or more of dichloromethane, diethyl ether and thiophene. According to the method of the disclosure, D-mannose is taken as a raw material, D-fucose is obtained simply, conveniently and efficiently, depending on suitable mixed solvents, the uniform construction of a cis-glycosidic bond of the D-fucose is achieved, the stereoselectivity can be up to 100%, and a very good application prospect in the aspects of the development of novel medicines and vaccines againstand the like is achieved.