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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12133884 B1

PDFFull Text
Date of Patent:
Nov. 05, 2024

Filed:

May. 11, 2019

Methods of substituting pathogenic amino acids using programmable base editor systems

Applicant:

Beam Therapeutics Inc., Cambridge, MA (US);

Inventors:

David Bryson, Cambridge, MA (US);

John Evans, Cambridge, MA (US);

Michael Packer, Cambridge, MA (US);

Yanfang Fu, Cambridge, MA (US);

Nicole Gaudelli, Cambridge, MA (US);

Jason Michael Gehrke, Cambridge, MA (US);

J. Keith Joung, Cambridge, MA (US);

Assignee:

Beam Therapeutics Inc., Cambridge, MA (US);

Attorneys:

Melissa Hunter-Ensor

Nicholas Ballor

Greenberg Traurig, LLP

Primary Examiner:

Suzanne M Noakes

Assistant Examiner:

Jae W Lee

Int. Cl.
CPC ...
A61K 38/50 (2006.01); A61K 31/7088 (2006.01); A61K 38/46 (2006.01); C07K 14/805 (2006.01); C12N 9/22 (2006.01); C12N 9/78 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A61K 38/50 (2013.01); A61K 31/7088 (2013.01); A61K 38/465 (2013.01); C12N 9/22 (2013.01); C12N 9/78 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 15/907 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract

Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

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Quick Actions:

Bryson, David. (2024). Methods of substituting pathogenic amino acids using programmable base editor systems (U.S. Patent No. 12133884). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12133884

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