The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 05, 2024

Filed:

Jan. 06, 2023
Applicants:

University of Washington, Seattle, WA (US);

Fred Hutchinson Cancer Research Center, Seattle, WA (US);

Inventors:

John R. Chevillet, Seattle, WA (US);

Tatiana D. Khokhlova, Seattle, WA (US);

George R. Schade, Seattle, WA (US);

Joo Ha Hwang, Bellevue, WA (US);

Muneesh Tewari, Seattle, WA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/15 (2006.01); A61B 8/08 (2006.01); A61B 10/00 (2006.01); A61N 7/02 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
A61B 5/14546 (2013.01); A61B 5/145 (2013.01); A61B 5/14507 (2013.01); A61B 5/15 (2013.01); A61B 5/4836 (2013.01); A61B 8/08 (2013.01); A61B 8/5223 (2013.01); A61B 10/0038 (2013.01); A61B 10/007 (2013.01); A61N 7/022 (2013.01); C12Q 1/6886 (2013.01); A61B 2010/0077 (2013.01); A61N 7/02 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.


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