The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2024
Filed:
May. 23, 2019
Applicant:
National University of Singapore, Singapore, SG;
Inventors:
Dario Campana, Singapore, SG;
Natasha Vinanica, Singapore, SG;
Yi Tian Png, Singapore, SG;
Takahiro Kamiya, Tokyo, JP;
Assignee:
National University of Singapore, Singapore, SG;
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 35/17 (2015.01); C07H 21/04 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/63 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 35/17 (2013.01); C07K 14/70507 (2013.01); C07K 14/7051 (2013.01); C07K 14/70578 (2013.01); C07K 16/2806 (2013.01); C12N 5/0646 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C07K 2319/04 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention provides engineered immune cells comprising an anti-CD2 protein expression blocker (PEBL) and an anti-CD2 chimeric antigen receptor (CAR). In some embodiments, such engineered immune cells lack surface expression CD2. Also, provided herein are methods of using such cells in cancer therapies.