The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2024

Filed:

Feb. 22, 2021
Applicants:

Reprobiogen Inc., Toronto, CA;

Shangmian Yie, Toronto, CA;

Rong Xiao, Toronto, CA;

Inventors:

Clifford L. Librach, Toronto, CA;

Shangmian Yie, Toronto, CA;

Rong Xiao, Toronto, CA;

Assignee:

REPROBIOGEN INC., Toronto, CA;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/073 (2010.01); A01N 1/02 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0605 (2013.01); A01N 1/021 (2013.01); A01N 1/0284 (2013.01); C12N 2509/00 (2013.01);
Abstract

A method of isolating a pluripotent cell from human umbilical cord is described herein. Cells so isolated may be reprogrammed as pluripotent cells and differentiated for use in cardiovascular treatment, may be used in screening cardiovascular drug candidates, or may be used in cell-based and cell-free therapy for inflammatory conditions. The method involves collecting a sample of umbilical cord from fetal tissue obtained at less than 13 weeks of gestation, for example a first trimester umbilical cord. The sample is treated to obtain isolated umbilical cord cells, after which the isolated umbilical cord cells are incubated. Cells obtained in this way can be differentiated for use in treating conditions of cell damage, by supplanting the function of a damaged cell in a condition such as spinal cord injury, cardiovascular injury or heart disease.


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