The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2024
Filed:
Dec. 28, 2021
University of Washington, Seattle, WA (US);
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Daniel Ellis, Seattle, WA (US);
Neil King, Seattle, WA (US);
Jesse Bloom, Seattle, WA (US);
Tyler Starr, Seattle, WA (US);
Allison Greaney, Seattle, WA (US);
UNIVERSITY OF WASHINGTON, Seattle, WA (US);
FRED HUTCHINSON RESEARCH CENTER, Seattle, WA (US);
Abstract
Provided herein are compositions and methods comprising mutated coronavirus 'S' spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.