The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2024
Filed:
Sep. 14, 2021
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
David P. Corey, Cambridge, MA (US);
Casey A. Maguire, Arlington, MA (US);
Killian S. Hanlon, Cambridge, MA (US);
Maryna V. Ivanchenko, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.