The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2024
Filed:
Apr. 02, 2018
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Edward E. Morrisey, Newtown Square, PA (US);
Jason A. Burdick, Philadelphia, PA (US);
Leo Wang, Philadelphia, PA (US);
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/06 (2006.01); A61K 31/7105 (2006.01); A61K 47/36 (2006.01); A61P 9/04 (2006.01);
U.S. Cl.
CPC ...
A61K 9/06 (2013.01); A61K 31/7105 (2013.01); A61K 47/36 (2013.01); A61P 9/04 (2018.01);
Abstract
The present disclosure provides microRNA-based therapies using a hydrogel delivery system that provides regenerative approach to myocardial infarction by targeting cardiomyocytes. The hydrogel provides for local and sustained cardiac delivery of microRNAs, such miR-302 mimics that can be used to promote cardiomyocyte proliferation. Also provided are compositions suitable for local and sustained release and methods for intramyocardial gel delivery of a miRNA oligonucleotide.