The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2024

Filed:

Apr. 25, 2019
Applicant:

University of Iowa Research Foundation, Iowa City, IA (US);

Inventors:

Michael K. Schultz, Iowa City, IA (US);

Christopher Pigge, Iowa City, IA (US);

Mengshi Li, Iowa City, IA (US);

Moustafa Gabr, Iowa City, IA (US);

Edwin Sagastume, Iowa City, IA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); A61K 45/06 (2006.01); A61K 51/08 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0482 (2013.01); A61K 45/06 (2013.01); A61K 51/0497 (2013.01); A61K 51/083 (2013.01);
Abstract

A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R-Ris independently selected from the group consisting of CHCOORand CHC(═O)NHR; each of R-Ris independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.


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