The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2024
Filed:
Aug. 24, 2023
Dyne Therapeutics, Inc., Waltham, MA (US);
Timothy Weeden, Waltham, MA (US);
Scott Hilderbrand, Cambridge, MA (US);
Sean Spring, Waltham, MA (US);
Peiyi Shen, Waltham, MA (US);
Cody A. Desjardins, Waltham, MA (US);
Romesh R. Subramanian, Framingham, MA (US);
Mohammed T. Qatanani, Waltham, MA (US);
Brendan Quinn, Boston, MA (US);
John Najim, Waltham, MA (US);
Dyne Therapeutics, Inc., Waltham, MA (US);
Abstract
Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes (e.g., wherein each complex is of the exemplary formula shown below) comprising a phosphorodiamidate morpholino oligomer (e.g., useful for targeting DMD) covalently linked to an antibody (e.g., anti-TfR1 antibody). In some embodiments, the complexes are formulated with histidine (e.g., L-histidine) and sucrose at a specified pH (e.g., about 5.0 to 7.0). Also provided are uses of these formulations for treating a subject having a mutated DMD allele associated with Duchenne Muscular Dystrophy.