The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2024

Filed:

Jun. 12, 2020
Applicant:

Quantum-si Incorporated, Guilford, CT (US);

Inventors:

Jonathan M. Rothberg, Guilford, CT (US);

Ali Kabiri, Guilford, CT (US);

Jason W. Sickler, Arlington, MA (US);

Brett J. Gyarfas, Aptos, CA (US);

Jeremy Lackey, Foster City, CA (US);

Gerard Schmid, Guilford, CT (US);

Assignee:

Quantum-Si Incorporated, Branford, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); C12Q 1/6869 (2018.01); C12Q 1/6874 (2018.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6486 (2013.01); B01L 3/5085 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6874 (2013.01); G01N 21/64 (2013.01); G01N 21/645 (2013.01); G01N 21/6452 (2013.01); G01N 21/648 (2013.01); G01N 21/7743 (2013.01); G01N 21/7746 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/0893 (2013.01); B01L 2300/168 (2013.01); C12Q 2521/101 (2013.01); C12Q 2525/101 (2013.01); C12Q 2537/157 (2013.01); C12Q 2563/107 (2013.01); C12Q 2565/607 (2013.01); G01N 2021/6419 (2013.01); G01N 2021/6441 (2013.01); G01N 2021/6478 (2013.01); G01N 2201/02 (2013.01); G01N 2201/06113 (2013.01); G01N 2201/0612 (2013.01); G01N 2201/062 (2013.01); G01N 2201/068 (2013.01); G01N 2201/125 (2013.01); Y10T 29/49016 (2015.01);
Abstract

An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.


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