The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2024

Filed:

Mar. 26, 2020
Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Elizabeth Anne Aisenbrey, Madison, WI (US);

William Leo Murphy, Waunakee, WI (US);

Elizabeth Emma Torr, Madison, WI (US);

Victoria Harms, Madison, WI (US);

Gaurav Kaushik, Madison, WI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/09 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0693 (2013.01); C12N 2500/50 (2013.01); C12N 2501/734 (2013.01); C12N 2501/998 (2013.01); C12N 2502/086 (2013.01); C12N 2502/088 (2013.01); C12N 2502/28 (2013.01); C12N 2502/30 (2013.01);
Abstract

The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particular, provided herein are methods of producing and using complex, highly uniform vascularized brain cancer organoids that comprise physiologically relevant human cells and have the high degree of sample uniformity and reproducibility required for use in high-throughput screening applications.


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