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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12122827 B1

PDFFull Text
Date of Patent:
Oct. 22, 2024

Filed:

Apr. 26, 2023

Il-21 polypeptides and targeted constructs

Applicant:

Asher Biotherapeutics, Inc., South San Francisco, CA (US);

Inventors:

Yik Andy Yeung, South San Francisco, CA (US);

Renee L. Greer, Pacifica, CA (US);

Henry C. Nguyen, San Francisco, CA (US);

David Liu, Pacifica, CA (US);

Byong Kang, San Francisco, CA (US);

Ivana Djuretic, Pacifica, CA (US);

Assignee:

ASHER BIOTHERAPEUTICS, INC., South San Francisco, CA (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Jeffrey Stucker

Assistant Examiner:

Brittney E Donoghue

Int. Cl.
CPC ...
C07K 16/24 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/244 (2013.01); A61P 35/00 (2018.01); C07K 14/54 (2013.01); C07K 16/2815 (2013.01); C07K 16/40 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/565 (2013.01); C07K 2317/64 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Find Patent Forward Citations

Yeung, Yik. (2024). Il-21 polypeptides and targeted constructs (U.S. Patent No. 12122827). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12122827

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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