The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2024
Filed:
Jun. 21, 2018
Oslo Universitetssykehus Hf, Oslo, NO;
Consejo Superior DE Investigaciones Científicas, Madrid, ES;
Universitat Politécnica DE València, Valencia, ES;
National and Kapodistrian University of Athens, Athens, GR;
Georgios C. Vougioukalakis, Attica, GR;
Georgios Rotas, Attica, GR;
Theodossis A. Theodossiou, Oslo, NO;
Kristian Berg, Heggedal, NO;
Ángel Miranda Alonso Miguel, Valencia, ES;
OSLO UNIVERSITETSSYKEHUS HF, Oslo, NO;
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, Madrid, ES;
UNIVERSITAT POLITÉCNICA DE VALÊNCIA, Valencia, ES;
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, GR;
Abstract
The invention provides mitochondria-targeted chemiluminescent agents and their use in methods of photodynamic therapy (PDT). In particular, the invention provides compounds of general formula (I), and their pharmaceutically acceptable salts: (I) in which A represents a chemiluminescent moiety; each L, which may be the same or different, is either a direct bond or a linker; each B, which may be the same or different, represents a mitotropic moiety; n is an integer from 1 to 3, preferably 1; and x is an integer from 1 to 3, preferably 1. Such compounds find particular use in the treatment of deeply-sited tumours, e.g. glioblastoma multiforme (GBM), when used in combination with a photosensitizer or photosensitizer precursor.