The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2024
Filed:
Jan. 18, 2022
Takeda Pharmaceutical Company Limited, Osaka, JP;
Gaozhong Zhu, Weston, MA (US);
Kris Lowe, Boston, MA (US);
Zahra Shahrokh, Weston, MA (US);
James Christian, Grafton, MA (US);
Richard Fahrner, Boxford, MA (US);
Jing Pan, Boxborough, MA (US);
Teresa Leah Wright, Lexington, MA (US);
Pericles Calias, Melrose, MA (US);
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.