The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Jul. 19, 2021
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
David Barbie, Andover, MA (US);
Russell W Jenkins, Boston, MA (US);
Cloud P. Paweletz, Boston, MA (US);
Elena Ivanova, Brookline, MA (US);
Amir Aref, Natick, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); C12M 3/06 (2006.01); C12N 1/04 (2006.01); C12N 9/64 (2006.01); C12Q 1/6869 (2018.01); C12Q 1/6881 (2018.01); G01N 33/50 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12M 23/16 (2013.01); C12N 1/04 (2013.01); C12N 9/6491 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6881 (2013.01); G01N 33/5082 (2013.01); G01N 33/582 (2013.01); C12Y 304/24007 (2013.01);
Abstract
Methods are provided for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods are also described for allowing ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.