The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Jun. 14, 2021
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Grant E. Blouse, Burlingame, CA (US);
Brajesh Kumar, Fremont, CA (US);
Tom Knudsen, Burlingame, CA (US);
Jan Kristian Jensen, Randers, DK;
Emil Oldenburg, Aarhus, DK;
Christine René Schar, Randers, DK;
Matthew John Traylor, Boulder, CO (US);
Eric Steven Furfine, Lincoln, MA (US);
Jeffrey Charles Way, Cambridge, MA (US);
Agnieszka Jendroszek, Risskov, DK;
Arzu Sandikci, Berkeley, CA (US);
Jim McGuire, South San Francisco, CA (US);
Shyam Rajan Iyer, Woodside, CA (US);
Natacha Le Moan, South San Francisco, CA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
Provided herein are Complement Factor I (CFI) variants that exhibit at least one improved characteristic relative to a wild type CFI. CFI variants of the disclosure can exhibit tunable specificity and activity. Also included are CFI-containing fusion constructs comprising at least one domain of CFI, for example, wild type full length CFI fused to human serum albumin. Also included are methods of making and using such CFI variants and fusion constructs. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.