The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2024

Filed:

Sep. 17, 2019
Applicant:

The Lundquist Institute for Biomedical Innovation AT Harbor-ucla Medical Center, Torrance, CA (US);

Inventors:

Liana Chan, San Pedro, CA (US);

Scott G. Filler, San Pedro, CA (US);

Michael R. Yeaman, Redondo Beach, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); A61K 35/74 (2015.01); A61P 31/04 (2006.01); C12N 5/0786 (2010.01); C12R 1/445 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0645 (2013.01); A61K 35/74 (2013.01); A61P 31/04 (2018.01); C12N 1/20 (2013.01); C12N 2500/72 (2013.01); C12R 2001/445 (2021.05);
Abstract

Cell populations, compositions, and methods are provided relating to target priming of macrophage cells. The macrophages, once primed or activated with a microorganism, can be used to prevent or treat infection by the microorganism. Likewise, once primed or activated by a tumor cell or tumor antigen, the macrophage cell can be used to prevent or treat tumor of the same kind. The priming can be carried out in vitro or ex vivo. The macrophages can be isolated from the subject of disease prevention or treatment.


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